The exact coordination of cellular metabolism is fundamental to homeostasis and its dysregulation triggers a variety of diseases including diabetes, cardiovascular disease, atherosclerosis, obesity, cancer and neurological disorders. The focus in this area is on different aspects of cellular metabolism and signaling: transcriptional mechanisms of fasting, fasting to overcome therapy-resistant liver cancer, endothelial function, endothelial lipase and HDL, lipases and lipid signaling, lipolysis in lysosomes and lipid droplets and biophysics of ion channels.
