PI: Dagmar Kratky
Focus: Storage and degradation of lipids are tightly regulated processes involving intracellular lipid hydrolases, enzymes of lipid biosynthesis, and regulatory proteins. Excessive lipid accumulation is central in the pathogenesis of prevalent metabolic diseases such as obesity, diabetes, and atherosclerosis. Our team investigates the function of lipid hydrolases in the regulation of lipid and energy metabolism in the whole organism as well as in specific organs (e.g. liver, small intestine, adipose tissue) and cells (hepatocytes, enterocytes, adipocytes). Furthermore, we are interested in the role of lipid hydrolases in macrophages with regard to the development of atherosclerosis.
Network: Within the Gottfried Schatz Research Center, our team works closely together with the research teams of Wolfgang Graier (energy metabolism), Tobias Madl (metabolomics), Wolfgang Sattler (lipid metabolism), Roland Malli (fluorescent probes) und Sasa Frank (lipoprotein metabolism). We cooperate across departments with groups of the division of Cell Biology, Histology and Embryology, in particular with Dagmar Kolb (electron microscopy), Andreas Prokesch (transcription factors and fasting) und Martin Gauster (placental histology).